Apresia®
Understanding Skin Rejuvenation
With the Advancements of Biochemistry
The skin is a regenerative organ and given the opportunity and stimulation it will repair itself. This can be seen with deep chemical peels, dermabrasion and laser peels that produce a controlled deep skin injury. The dramatic improvements in the skin's appearance following these procedures is caused by the skin's immune and repair processes. The peel only serves as an instrument that produces an injury and thereby stimulates the natural repair processes.
Repair processes are regulated by a group of skin chemicals called "cytokines." They include epidermal cell growth factor (ECGF), transforming growth factor (TGF), angiogenesis factor (AF), platelet-derived growth factor (PDGF), interleukin (IL), interferon (IF) and a number of others. Cytokines are produced by the cellular components of skin on a routine basis and in large amounts as a result of injury.
Angiogenesis factor (AF) stimulates the rebuilding of the microvascular system and it comes into immediate action following injuries, especially cuts and abrasions. Transforming growth factor (TGF) and epidermal cell growth factor (ECGF) stimulate rapid cell development to replace dead or damaged cells and stimulate the formation of collagen and elastin to bind the wound together. Other cytokines, such as interleukin (etc.) assist in these functions and protect against infection.
Volumes of research have been published on the precise roles of vitamin A within the skin. Vitamin A is able to attach to receptors on macrophages cells (specialized skin cells involved in immune and repair functions). The macrophage cells then produce AF and TGF, stimulating enhancement of the microvascular system and production of elastic fibers. These repair functions have long-term benefits.
Most anti-aging cosmetic products contain very little vitamin A and provide little rejuvenating benefit. Apresia's Vitamin A Intensive Concentrate contains more than ten times the concentration of vitamin A as contained in most skin rejuvenation products and it produces results comparable to prescriptive products.
Other natural chemicals, such as betaglucan (a yeast derivative) and panthenol (vitamin B5) produce similar benefits. Betaglucan stimulates the production of ECGF and AF. It has been used for several years on post-surgical incisions, in the treatment of skin donor sites following skin grafts and more recently following cosmetic laser surgery.
Panthenol has similar benefits and assists in up-regulating total cytokine response. Science has long recognized the importance of the vitamin B group in the healing and repair process, as well as its inhibition of cancer and disease. Research is under way regarding the exact mechanisms of panthenol in the repair and rejuvenation of skin.
These ingredients, and many other important natural bio-chemicals, are found in Apresia's Mature Skin Care products (Vitamin A Intensive Concentrate and Nighttime Cream Bio-Essentials) in high concentrations and in Skin Nourishing Moisturizer. The ingredients in these products produced the skin rejuvenation seen in the before and after photographs.
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